Table 1 Summary of total number of cells and mice injected per condition for primary (1°) and secondary (2°) transplants

From: Gene correction for SCID-X1 in long-term hematopoietic stem cells

Genome editing condition transplanted into NSG mice 1° Human transplant studies total nr. of cells injected per condition 1° Human transplant studies total nr. of mice per condition (end point) 2° Human transplant studies total nr. of cells injected per condition 2° Human transplant studies total nr. of mice per condition (end point)
WT 2.0 × 106 4 n/a n/a
Mock targeted 5.7 × 106 15 4.3 × 106 12
RNP only targeted 2.0 × 106 4 1.5 × 106 4
IL2RG cDNA targeted 9.7 × 106 24 8.0 × 106 20
Total 19.3 × 106 47 13.8 × 106 36