Fig. 3 | Nature Communications

Fig. 3

From: Gene correction for SCID-X1 in long-term hematopoietic stem cells

Fig. 3

Normal multi-lineage development from IL2RG cDNA targeted in the LT-HSC population. a Percent cellular composition of the lymphoid, myeloid and erythroid lineage derived from IH 1° human engraftment, shown in indicated organs and targeting conditions. CD3BM: **p = 0.0017, CD3+SP: **p = 0.007 (Welch’s t-test). b Same as (a) but IF transplant analysis. CD3SP: *p = 0.023, CD56BM: *p = 0.015 (Kruskal–Wallis test). c Percent cellular composition of the lymphoid, myeloid and erythroid lineage derived from secondary transplants. Data shown are combined IH and IF primary transplants. CD3BM: *p = 0.015, CD56+: *p = 0.025, CD19+ SP: ***p = 0.0002, CD14+ SP: *p = 0.0112, CD11c+ SP: ***p = 0.0004. LT long term. Error bars: mean ± s.e.m. Source data are available in the Source Data file

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