Fig. 4 | Nature Communications

Fig. 4

From: Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif

Fig. 4

NaV1.4 CTerm and NaV1.5 CTerm populations with bound CaM. a Reaction scheme of Ca2+ ions binding to CaM lobes. Thermodynamic data of these binding reactions were reported previously18, 19. b Reaction scheme of CaM in four Ca2+-saturation states binding to NaV CTerm. Thermodynamic data of these binding reactions are reported here. c–f Panels showing the relative population (Z-axis) of four CaM species bound to NaV CTerm, modeled as a function of [Ca2+] and [CaM] using the two schemes above. NaV1.4 CTerm-bound species on the left, NaV1.5 CTerm-bound CaM-species on the right. c Population of apo CaM bound to NaV CTerm. d Population of (Ca2+)2-N–CaM bound to NaV CTerm. e Population of (Ca2+)2-C–CaM bound to NaV CTerm. f Population of (Ca2+)4–CaM bound to NaV CTerm. Only NaV1.4 CTerm shows a significant population of bound (Ca2+)2-C–CaM (orange surface)

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