Fig. 2 | Nature Communications

Fig. 2

From: Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif

Fig. 2

Structures of NaV1.4 CTerm in complex with CaM, ± Ca2+. a 1.8 Å resolution structure of the complex of the NaV1.4 CTerm and apo CaM. CTerm colored gray and CaM light teal (N-lobe) and light orange (C-lobe). b Close-up of the apo C-lobe and helix α VI interactions. c Close-up of N-lobe and EFL interaction. d 3.3 Å resolution structure of the complex of the NaV1.4 CTerm and (Ca2+)4-CaM. CTerm is colored black and CaM dark teal (N-lobe) and dark orange (C-lobe). e Close-up of Ca2+-C-lobe and helix αVI interactions. f Close-up of Ca2+-N-lobe and EFL interaction. Residues shown have more than 10 Å2 BSA. g–i Schematics of CaM N-lobe control in NaV regulation. g Activated conformation of CaM and NaV1.4 (PDB ID: 6MBA). h Ca2+-inactivated conformation of CaM and NaV1.4 (PDB ID: 6MC9). i Ca2+-insensitive conformation of CaM and NaV1.5 (PDB ID: 4JQ0, FHF molecule not displayed)

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