Fig. 8 | Nature Communications

Fig. 8

From: A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif

Fig. 8

Pit2 effector act as molecular mimicry. Mechanism of substrate cleavage by active PLCPs (left panel) consisting of substrate recognition (1), substrate cleavage (2) and product release (3). To avoid activation of the immune system, U. maydis secretes the apoplastic effector Pit2 that contains the PID motif of 14 amino acids. In the molecular mimicry substrate model (right panel), active PLCPs recognize Pit2 as a substrate (1). Next, PLCPs cleave Pit2 similar to endogenous substrates (2). While cleavage products endogenous substrates are released from the active site, the inhibitory portion of Pit2 embedded in the PID14 remains bound to the PLCP and thereby blocks its activity

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