Fig. 2 | Nature Communications

Fig. 2

From: Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

Fig. 2

Neuronal inhibition of autophagy impairs age-sensitive olfactory memory. a Aversive associative memory performance 3 min after training (short-term memory, STM) markedly reduced in elav/atg5-RNAi compared to +/atg5-RNAi (n = 17–18; ***p < 0.001; Mann–Whitney U-test). b STM significantly reduced in elav/atg9-RNAi compared to +/atg9-RNAi (n = 6–8; *p < 0.05; Mann–Whitney U-test). c Aversive associative memory performance at 1 h after training (mid-term memory; MTM) of elav/atg5-RNAi declined significantly compared to +/atg5-RNAi (n = 11–16; **p < 0.01; Mann–Whitney U-test). d MTM significantly reduced in elav/atg9-RNAi flies compared to +/atg9-RNAi (n = 8–12; *p < 0.05; Mann–Whitney U-test). e STM significantly reduced in ok107/atg5-RNAi flies compared to +/atg5-RNAi (n = 17–20; ***p < 0.001; Mann–Whitney U-test). f STM significantly reduced in vt30559/atg5-RNAi flies compared to +/atg5-RNAi (n = 9; ***p < 0.0001; Mann–Whitney U-test). g STM significantly reduced in ok107/atg9-RNAi flies compared to +/atg9-RNAi (n = 12–14; **p < 0.01; Mann–Whitney U-test). h MTM significantly reduced in ok107/atg9-RNAi flies compared to +/atg9-RNAi (n = 10–12; *p < 0.05; Mann–Whitney U-test). i Aversive associative memory performance at 1 h after training, anesthesia-resistant memory (ARM) and j anesthesia-sensitive memory (ASM) of elav/atg9-RNAi compared to +/atg9-RNAi (n = 7–10; *p < 0.05; nsp > 0.5; Mann–Whitney U-test). k ARM and l ASM of ok107/atg9-RNAi compared to +/atg9-RNAi (n = 15–17; **p < 0.01; nsp > 0.5; Mann–Whitney U-test). In the box and whisker plots, the middle line of a box represents the median (50th percentile) and the terminal lines of a box represent the 25th and 75th percentile. The whiskers represent the lowest and the highest value

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