Fig. 6 | Nature Communications

Fig. 6

From: Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

Fig. 6

GITR engagement effects are dependent on GITR on ILC2s and IL-13. a A cohort of GITR-/- mice were adoptively transferred or not with ILC2s from WT mice. After the adoptive transfer, mice were treated with DTA-1 (1 mg/mouse) or isotype control and fed on HFD for 14 weeks according to the scheme, n = 8. b Total weight and c fasting blood glucose levels were measured every two weeks for 14 weeks. d Glucose tolerance test was performed after 14 weeks of treatment. e A cohort of GITR-/- mice were adoptively transferred with ILC2s from either WT, IL-5-/-, or IL-13-/- mice. After the adoptive transfer, mice were treated with DTA-1 or isotype control and fed on HFD for 14 weeks according to the scheme, n = 8. f Total weight and g fasting blood glucose levels were measured every two weeks for 14 weeks. h Glucose tolerance test was performed after 14 weeks of treatment. VAT weight (i) was measured and number of ILC2s per gram of VAT (j) was quantified 14 weeks after adoptive transfer. Error bars are the mean ± SEM. Student’s t-test, **p < 0.01, ***p < 0.001. Mouse image provided with permission from Servier Medical Art

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