Fig. 5 | Nature Communications

Fig. 5

From: Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

Fig. 5

Therapeutic GITR treatment ameliorates established Type 2 Diabetes in Rag2-/- mice. a A cohort of Rag2-/- mice were fed on HFD for 14 weeks. After 8 weeks, mice were either treated with DTA-1 (1 mg/mouse) or isotype control by intraperitoneal injection every four days according to the scheme, n = 8. b Total weight and c fasting blood glucose levels were measured every two weeks for 14 weeks. d Plasma insulin concentration was measured by ELISA. e Glucose tolerance test and f insulin tolerance test were performed in a cohort of mice after 8 weeks of treatment. The corresponding area under the curve was calculated for each group. g Hematoxylin and eosin-stained epididymal adipose tissue sections (×400). Red arrows point to recruited inflammatory cells around adipocytes, scale bars, 100 µm. h Corresponding quantitation presented as the mean adipocyte area. i Weight of the VAT (epididymal adipose tissue) after 8 weeks of treatment. Error bars are the mean ± SEM. Student’s t-test, p < 0.05, **p < 0.01, ***p < 0.001. Mouse image provided with permission from Servier Medical Art

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