Table 2 Estimates of α for 25 UK Biobank traits

From: Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

Phenotype Sample size \(\hat{\mathbf{\alpha}}\) [95% CI]
Age of menarche 58,329 −0.40 [−0.63, −0.11]
Blood pressure (diastolic) 104,835 −0.39 [−0.54, −0.20]
Blood pressure (systolic) 104,835 −0.38 [−0.54, −0.18]
BMI 113,540 −0.24 [−0.38, −0.06]
Bone mineral density 110,611 −0.35 [−0.45, −0.23]
FEV1/FVC 97,075 −0.44 [−0.55, −0.31]
FVC 97,075 −0.15 [−0.31, 0.04]
Height 113,660 −0.45 [−0.52, −0.39]
Smoking status 113,560 −0.16 [−0.43, 0.21]
Waist-hip ratio 113,668 −0.17 [−0.43, 0.19]
Allergic eczema 113,707 −0.60 [−0.85, −0.26]
Asthma 113,707 −0.25 [−0.60, 0.28]
College education 112,811 −0.32 [−0.54, −0.04]
Hypertension 113,689 −0.18 [−0.46, 0.21]
Eosinophil count 108,957 −0.40 [−0.54, −0.24]
High light scatter reticulocyte count 108,785 −0.53 [−0.65, −0.38]
Lymphocyte count 108,664 −0.52 [−0.63, −0.38]
Mean corpuscular hemoglobin 108,513 −0.42 [−0.53, −0.31]
Mean sphered cell volume 109,523 −0.43 [−0.56, −0.28]
Monocyte count 110,026 −0.19 [−0.35, −0.01]
Platelet count 109,971 −0.19 [−0.32, −0.03]
Platelet distribution width 109,938 −0.27 [−0.44, −0.07]
Red blood cell count 110,054 −0.39 [−0.51, −0.25]
Red blood cell distribution width 109,913 −0.20 [−0.36, −0.01]
White blood cell count 110,186 −0.25 [−0.42, −0.03]
  1. We computed α estimates for 25 UK Biobank traits, including 10 quantitative traits, 4 case–control traits, and 11 blood cell traits (all quantitative). The reported 95% credible intervals were calculated from the profile likelihood curves using a flat prior