Fig. 1 | Nature Communications

Fig. 1

From: Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

Fig. 1

Fraction of SNP-heritability in different MAF ranges given α. We report the fraction of SNP-heritability explained by SNPs up to a certain MAF (x-axis), for different values of α. For example, assuming α = −0.4, SNPs with MAF ≤ 5% collectively explain about 20% of the total SNP-heritability. These results are based on the UK10K allele frequency spectrum and our model assumption that squared per-allele effects are proportional to [2p(1 − p)]α. Source data are provided as a Source Data file

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