Fig. 3 | Nature Communications

Fig. 3

From: A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia

Fig. 3

Summary of GWAS findings. Results are presented for six pigmentation traits: skin melanin index (MI, quantitative), categorical hair color, categorical eye color, and three quantitative eye color variables extracted from digital photographs: L (lightness/brightness), C (chroma/saturation) and cos H (cos hue/tone). These traits are represented on the right. The HCL color space with the three axes of variation is shown in the inset. To provide a global summary of the results, a composite Manhattan plot is presented at the bottom combining significant signals for all the traits. Horizontal lines indicate the suggestive (blue line, P value = 1 × 10−5) and significant (red line, P value = 5 × 10−8) thresholds. The y-axis was truncated at –log10(P value) = 14. Index SNPs in each region are listed above the Manhattan plot. The association of these SNPs with specific traits is represented by colored boxes at the top: a box is shown if a SNP is associated with that trait (Table 1). Box colors correspond to colors assigned to each chromosome in the Manhattan plot, with slight variation when multiple independent hits were observed on the same chromosome. Novel genomic regions are marked with an asterisk

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