Fig. 1 | Nature Communications

Fig. 1

From: Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects

Fig. 1

Segmental body impedance analyses. This method uses bio-electrical impedance to estimate body composition: fat mass, muscle mass, etc. In this study, adipose tissue mass was estimated using the Tanita BC-418MA body composition analyzer (a). This machine uses an eight-electrode method, which allows for five measurements of impedance. Electrical current is supplied to the front of both feet and the fingertips of both hands. Voltage is measured on either heel or thenar portion of the palms. Body composition is derived from a regression formula for each body part. The formula is derived from regression analysis using height, weight, age and impedance for each body part as predictors for composition of each body part as assessed by DXA (b). GWAS for AFR, LFR, and TFR were conducted in the UK Biobank cohort and revealed associations with loci that have not previously been associated with standard anthropometric traits. c A manhattan plot with combined results for association studies of body fat ratios in combined and sex-stratified analyses. Overall, 135 independent associations with at least one of the body fat ratios were observed in the discovery analyses. Out of the initial 135 associations, 98 replicated; of which 30 replicated for AFR, 44 for LFR and 66 for TFR. Loci that have not previously been associated with an anthropomorphic trait are highlighted in red (N = 29)

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