Fig. 5 | Nature Communications

Fig. 5

From: Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep

Fig. 5

Fast gamma events lead hemodynamic patterns by 1.5 to 2 s. a Cross-correlation functions between four LFP envelope signals: Theta (6–10 Hz), Low-Gamma (20–50 Hz), Mid-Gamma (50–100 Hz), and High-Gamma (100–150 Hz) and three regional CBV signals (Thalamus, Hippocampus, Cortex) for n=28 REM episodes (six rats) lasting >30 s. Note that low-gamma shows no coupling with CBV signals in either region, theta shows moderate coupling, whereas both mid and high-gamma bands show strong robust coupling and reproducible LFP-CBV delays in all three regions. Each line shows one recording; gray dots show the peak of the cross-correlation function, which we used to extract the LFP-CBV delay of neurovascular coupling. b Mean cross-correlation functions for the 28 recordings shown above. Note that the delays follow the sequential activation pattern Thalamus-Hippocampus-Cortex described in Fig. 3. Color crosses display the peak of the mean cross-correlation function. c Histogram count of LFP-CBV delays extracted from the peak of cross-correlation function of high-gamma events. Note that LFP leads CBV for all recordings and shows some variability in the 1–3 s lag window. None of these delays was negative showing that LFP leads vascular activations in all 28 recordings

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