Fig. 3 | Nature Communications

Fig. 3

From: The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

Fig. 3

eQTL analysis for P. falciparum isolates in the GMS. a Scatter plot of 5575 high-confidence SNP-expression linkages with 2350 gene expression (y axis) against 3972 eQTLs (x axis). The statistical significance of each linkage is represented by the size of dot and the intensity of blue. The bar graph represents target genes for each eQTL. The scatter plot below represents eQTL enrichment along the chromosomes. The enrichment score was calculated as a ratio of observed and expected eQTL counts within a 50 kb window. The magenta dots denote eQTL hotspots. b Intra-chromosomal linkages are plotted as the significance (log transformed p-values) against the distance (between eQTL and target gene) for each linkage. The black lines represent average curves for a sliding window of 20 eQTLs. c Differential eQTL effects in isolates of (sub)regions of the GMS. LOD values are plotted for the w-GMS eQTLs against the e-GMS eQTLs where yellow dots stand for the local cis linkages and blue for the distal. The top right inset represents LOD values resulted from sub-sampling analysis of the 5575 high-confidence linkages in e-GMS (Methods)