Fig. 5 | Nature Communications

Fig. 5

From: Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands

Fig. 5

Significant changes in the frequencies of different lymphocyte subsets after measles. Frequency ratios of a naive or memory lymphocyte subsets or b functionally distinct T and B cell subsets (n = 42 paired samples). The ratio was calculated as the frequency of a subset after measles divided by the frequency of the same subset before measles. Horizontal dashed line indicates no changes (‘ratio = 1’) in frequency after measles. Ratio ‘>1’ indicates increase and ratio ‘<1’ indicates decrease in lymphocyte subset frequency after measles. Vertical dashed lines separate different lymphocyte subsets. Th1/17: Th1Th17 cells. CD27+IgM+IgD B cells are also known as IgM-only memory B cells. CD27+IgM+IgD+ B cells are also known as natural effector cells. TC: transitional B cells. Green box represents significant decrease. Orange box represents significant increase. Statistical differences in frequencies of lymphocyte subsets before and after measles were analysed by two-tailed paired t-test or Wilcoxon signed-rank test. Centre lines of the box plots represent medians. Lower and upper boundaries of the boxes represent first and third quartiles, respectively. Lower and upper whiskers represent the 10th and 90th percentiles of the data, respectively. Dots represent outliers. *P < 0.05; **P < 0.01; ***P ≤ 0.001