Fig. 1 | Nature Communications

Fig. 1

From: Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands

Fig. 1

Cohort A patient information. a Number of inclusions, completed samples and laboratory-confirmed measles cases of Cohort A. b The onset and the duration of pathognomonic symptoms of measles experienced by each child as observed and reported by the parents. Red line: rash; black line: fever; cyan line: conjunctivitis; dotted line: diarrhoea and/or vomiting; green line: cough; box: disease. c The numbers of T and B cells per 1 µl of blood of Cohort A children in comparison with those of age-matched healthy children (n = 23). Statistical differences in the absolute numbers of T and B cells in the blood of acute measles patients in comparison to age-matched healthy donors were analysed by Mann–Whitney rank sum test. Centre lines of the box plots represent medians. Lower and upper boundaries of the boxes represent first and third quartiles, respectively. Lower and upper whiskers represent the 10th and 90th percentiles of the data, respectively. Dots represent outliers. d The number of infected cells per one million PBMC and e, f infectious MV isolated from throat and nose swabs relative to the onset of rash (n = 23 donors). Each red dot represents a unique donor. Green shaded area indicates geometric mean of the samples from each time point. g The presence of MV-specific IgM in plasma of each Cohort A child relative to the onset of rash (n = 23 donors). Each red dot represents a unique donor. The green shaded area indicates the mean of the samples from each time point, the red line indicates the lowest threshold (ratio 1.1) of detection for reactive MV-specific IgM as indicated by the manufacturer, and the vertical dashed line represents the onset of rash

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