Fig. 3 | Nature Communications

Fig. 3

From: Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

Fig. 3

In vitro mixing experiments. Genomic DNA derived from liver (a), lung (b), neurons (c), and colon (d) (each from a single donor) was mixed in nine different combinations (detailed in Supplementary Data 1) with genomic DNA extracted from the blood of a single healthy donor, in the proportions indicated in the X axis. A total of 250 ng DNA from each mixture was subjected to an Illumina EPIC array, and the resulting methylome was deconvoluted to predict the contribution of each mixed-in tissue (Y axis). Each dilution point represents one mixing experiments

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