Fig. 2 | Nature Communications

Fig. 2

From: Molecular insights into genome-wide association studies of chronic kidney disease-defining traits

Fig. 2

Tissue expression profiles of CKD-dt GWAS SNPs. a General overview of CKD-dt GWAS SNPs and their expression profiles in different tissues. b Detailed overview of CKD-dt GWAS SNPs in relation to presence (blue) or absence (grey) of eGenes across different tissues; kidney data are from the TRANSLATE study and TCGA, GTEx—Genotype-Tissue Expression project, eSNP—transcriptionally active single-nucleotide polymorphism; kidney specificity was defined as (i) exclusive presence of eGene in the kidney or (ii) exclusive presence of eGene–CKD-dt GWAS eSNP association in kidney tissue (yellow dbSNP rsID label) or (iii) difference in identity of eGene partner between the kidney and non-kidney tissues (red dbSNP rsID label) or (iv) difference in direction of association of CKD-dt GWAS SNP with eGene between kidney and non-kidney tissues (green dbSNP rsID label)

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