Fig. 5 | Nature Communications

Fig. 5

From: A retrieval-specific mechanism of adaptive forgetting in the mammalian brain

Fig. 5

Prefrontal involvement declines after retrieval competition is resolved. a Representative images of cFos in the prefrontal cortex 90 min after the second practice trial (Early) or 90 min after the third practice trial (Late). Matched interference control groups were included and a time control group that remained in its home cage. b Number of cFos+ cells per mm2 in the prefrontal cortex expressed as means ± SEM for the Early and Late groups in the retrieval practice and interference control conditions (dotted line reports time control). Individual values used to calculate the mean and SEM are presented as dots. cFos was induced in the retrieval practice condition only in the Early group when competition needed to be resolved. ***p = 0.0008 (t23 = 4.16), d = 1.66 (Early vs. Late), Bonferroni post hoc comparisons, two-way ANOVA. c Discrimination index means ± SEM during test. Both Early and Late groups show forgetting. ***p = 0.0006 (t26 = 3.89), d = 1.42, unpaired t test. Retrieval practice early and late, n = 7 animals each; interference control early, n = 6 animals; interference control late n = 7 animals; time control, n = 6 animals. NS not significant

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