Fig. 6 | Nature Communications

Fig. 6

From: Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors

Fig. 6

MgPar regions of P110. a Sequence alignment of the KL variable region of P110 and different MgPars encompassing the sialic binding site. KL region of MgPar-3 carries several STOP codons within the aligned segment and it was not included in the analysis. Similarly, the MgPar-6 region was omitted because it does not contain variable sequences homologous to P110. Residues shown to be critical for cell adhesion in this work (black star) appear to be fully conserved in the KL variable region of all the MgPar repeats. These residues are also conserved in the M. pneumonia protein MPN_142, orthologous to P110 (lower part of the panel). b Two views, 90° apart from each other, of the P110 surface. The KL (residues 42–294 in red) and LM (residues 462–517 in blue) variable regions and the poly-Serine tract (409–419 in yellow) of the P110 protein are depicted. Variable regions surround the receptor binding site where a bound oligosaccharide is shown (green)

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