Fig. 4 | Nature Communications

Fig. 4

From: Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression

Fig. 4

Higher frequencies of terminally differentiated CD127 KLRG1 CD8+ TILs are present in melanoma tumors than breast tumors. a CD8+ T cells from bcPBMCs, bcTumor, and melTumor were assessed for expression of CD127 and KLRG1 by flow cytometry as shown in representative contour plots. b Graph depicts percentage of non-naive CD45RA CD8+ T cells that express a given expression pattern of CD127 and KLRG1. c Graphs depict the proportions of PD-1+ and PD-1 CD8+ T cells from bcTumor and melTumor with a given expression of CD127 and KLRG1. Each symbol represents data from a unique patient sample. Significance was calculated using one-way ANOVA and Holm–Sidak multiple comparison tests; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001

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