Fig. 2 | Nature Communications

Fig. 2

From: Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions

Fig. 2

The lifetimes of brain proteins. a Upper panel: distribution of 2381 lifetimes calculated in the brain cortex homogenate. Lower panel: lifetimes of 1266 proteins organized in 36 groups, accordingly to their organelle and/or functional affiliation, performed by integrating previously published categorizations19,20,21,22,23,24 (see also Supplementary Data 1). Each data point corresponds to a single protein lifetime. The black lines indicate the mean and the standard error of the mean (SEM) for each group. The analysis of variance (ANOVA) on the right summarizes P-values for the indicated comparisons, following Bonferroni post hoc test (*≤0.05, **≤0.01, ***≤0.001). b Lifetimes are positively correlated to protein abundances (determined with iBAQ), isoelectric point, and grand average of hydropathy (GRAVY). Lifetimes are negatively correlated to protein length and intrinsic disorder, while the correlation to mRNA abundances is not significant. The lines with error bars indicate averaged bins of 2 days, with SEM. Brain cortex homogenate data have been used in this figure and the protein and mRNA abundances were measured in this study, in the same preparation (brain cortex of the same mice)

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