Fig. 4 | Nature Communications

Fig. 4

From: Reprogramming of regulatory network using expression uncovers sex-specific gene regulation in Drosophila

Fig. 4

Validation of predicted DXS targets (predicted without genes highly expressed in ovary). a Enrichment of experimentally supported DSX targets recovered by different methods for female GRN. Enrichment for male GRN without testis is shown in Supplementary Table 11. b Precision-recall curves for predicting DSX targets for compared methods. The DSX targets predicted by each method are ranked by assigned weights. A high area under the curve corresponds to high precision (low false positive rate) and high recall (low false negative rate). As the ground truth we use DSX targets reported in ref. 30 based on ChiP-Seq occupancy and conserved motif scores. c Top 100 targets predicted by NetREX in the female GRN. d Enrichment of predicted DSX targets in genes with sex-biased expression for the female GRN. Different methods might predict different number of regulators for each gene. To fairly compare those GRNs we take for each method the k-best (k = 20) predictions for each gene. Comparison of other ks is shown in Supplementary Figure 8b. e Enrichment of DSX targets in sex differentially expressed genes by GSEA (Gene Set Enrichment Analysis)

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