Fig. 1 | Nature Communications

Fig. 1

From: Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma

Fig. 1

Chromatin accessibility analysis in acutely isolated human GSCs and NSPCs. a FACS plot showing isolation strategy of GBM and neural germinal matrix (GM) populations used for ATAC-seq preparation. See also Supplementary Fig. 1. b Differential ATAC-seq peak analysis between the union of E+GSC and E+NSPCs (n = 7) and E–GBM (n = 3) defines 5020 significantly enriched, developmentally shared peaks in E+GSCs. c Functional enrichment analysis of developmentally shared E+GSC peaks using GREAT. Illustrated are top significantly enriched gene ontology (GO) terms and examples of the corresponding annotated genes, which relate to stem-cell maintenance and proliferation. d Differential ATAC-seq peak analysis between E+GSC (n = 4) and the union of E–GBM and NSPCs (n = 9) defines 10,509 significantly enriched peaks unique to tumor E+GSCs. e Functional enrichment analysis of GSC tumor-specific peaks using GREAT. Illustrated are top significantly enriched GO terms and examples of the corresponding annotated genes, which relate cell migration, cell-substrate assembly, and EGFR signaling

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