Fig. 2 | Nature Communications

Fig. 2

From: LinCCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade

Fig. 2

Efficacy of HSC + PD-1 is dependent on both CD4 and CD8 lymphocytes. a KR158B glioma tumor-bearing mice received no treatment, PD-1 only, intracranial HSCs, intravenous HSCs, intracranial HSC + PD-1, or intravenous HSCs + PD-1 and observed for survival (*p = 0.0039, **p = 0.0056, *n/s p = 0.9491, n = 7 mice/group; Gehan–Breslow–Wilcoxon statistical test). b Glioma-bearing mice were depleted of CD4+ or CD8+ cells, then received either PD-1 or HSC + PD-1. Isotype + HSC + PD-1 served as the positive control (*p = 0.0001, **p = 0.0002, n = 7 mice/group; Gehan–Breslow–Wilcoxon statistical test). All error bars represent s.e.m.

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