Fig. 4 | Nature Communications

Fig. 4

From: Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

Fig. 4

Morphogenesis of aSyn fibril polymorphs arising from inter-protofilament packing. a Primary sequence of preNAC (blue) and NACore (red) critical for the aggregation of aSyn 1–140 and six PD familial mutations (cyan) located near the preNAC region. b Protofilaments sharing a kernel structure of a bent β-arch assemble into the rod and twister fibril polymorphs by packing at preNAC and NACore zipper interfaces, respectively. The PD familial mutations (cyan) likely disfavor the rod structure over the twister structures, and alter the polymorphic composition of aSyn fibrils

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