Fig. 2 | Nature Communications

Fig. 2

From: Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence

Fig. 2

Within-vector environment impacts within-host Plasmodium virulence. C57BL/6J mice bitten by P. berghei-infected mosquitoes (a, b) or infected by sporozoite injection (cf) were daily monitored for parasite occurrence in the blood and for symptoms of experimental cerebral malaria (ECM). a Kaplan–Meier analysis of time to infection (blood stage parasitemia) of mice infected by bites of control (Ctrl) or Lp-depleted (dsLp) mosquitoes (N—number of experiments: N = 4, n—total number of mice per each group: n = 10). **p < 0.001; log-rank test. b Cumulative health status of mice shown in a. c Kaplan–Meier analysis of time to infection (blood stage parasitemia), d incidence (%) of experimental cerebral malaria (ECM), and e parasitemia (mean ± SEM) in mice infected by subcutaneous injection of 5000 sporozoites dissected from the salivary glands of control (Ctrl) or Lp-depleted (dsLp) mosquitoes (N = 3, total number of mice in Ctrl and dsLp groups, n = 18 and n = 16, respectively). Asterisks indicate statistically significant differences (*p < 0.05; **p < 0.001; ***p < 0.0001 log-rank test (c, d) and two-sided Mann–Whitney test comparing Ctrl and dsLp conditions for each time point (e)). f Cumulative health status of mice shown in c, de

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