Fig. 3 | Nature Communications

Fig. 3

From: Exploring the role of stromal osmoregulation in cancer and disease using executable modelling

Fig. 3

Qualitative Network Model of the wider ion channel regulatory network. a, b Schematic of the network of ion channels involved in the model (a). Included are modules that involve osmotic regulation, calcium signalling, metabolism, and pH maintenance. Modules interact with each other heavily, and in particular osmotic regulation proteins are involved in many other modules. The schematic includes general trends of interactions, and does not show all nodes for completeness, but attempts to show the major protein types involved in each module, and the ionic behaviours considered. Individual nodes, however, can be much more complex than represented in the schematic, one example is shown in (b) of the Na-K-ATPase. In this case the Na-K-ATPase is split into two nodes, one representing the ion transport domain, and one representing the structural interactions of the domain. Both nodes interact with each other as they are part of the same protein, but subunits that associate in the protein complex elicit different effects. FXYD6 influences the ion transport domain only, whereas FXYD5 influences both the ion transport domain, and the structurally connected beta subunit domain, which interacts with the cytoskeleton and cell matrix independently of transport function. This separation of functional subdomains of the protein can also be used to incorporate phosphorylation states of the protein, where two nodes represent an unphosphorylated and phosphorylated state of the same protein

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