Fig. 6 | Nature Communications

Fig. 6

From: The concerted roles of FANCM and Rad52 in the protection of common fragile sites

Fig. 6

Inactivation of Rad52 drastically reduces the growth of FANCM KO cells and tumors. a, b Growth curve of HCT116 WT or FANCM KO cells was plotted after expressing Rad52 shRNA or control vector (a, left), or FANCM KO cells expressing FANCM WT or K117R followed by expression of Rad52 shRNA or control vector (b). The viability of HCT116 WT or FANCM KO cells expressing Rad52 shRNA or vector was analyzed by colony formation assay (a, right). c Tumor volume was measured in nude mice after tumor inoculation with HCT116 WT or FANCM KO cells expressing Rad52 shRNA or vector. Data are shown as the mean ± SD of tumor volumes of five mice in each group at each time point

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