Fig. 5 | Nature Communications

Fig. 5

From: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

Fig. 5

Genetic modifiers of KIV2-CN’s effect on lipoprotein(a) cholesterol. Three independent genetic modifiers of KIV2-CN’s effect on Lp(a)-C were discovered at the LPA locus. Regional association plots showing the variant-by-KIV2-CN interaction P values of all variants within a 1 Mb window of the LPA TSS are shown for African Americans (top) and Europeans (bottom), highlighting variants in linkage disequilibrium with rs1810126 (green), rs13192132 (red), and rs1840445 (blue), the top independent genome-wide significant variants (interaction P < 5 × 10−8) upon meta-analysis. KIV2-CN kringle IV-2 copy number, Lp(a)-C lipoprotein(a) cholesterol, TSS transcription start site