Retraction Note: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer

Retraction of: Nature Communications https://doi.org/10.1038/s41467-017-00508-5, published online 05 September 2017

In this Article, we reported that liver X receptors constrain metastatic development of prostate cancer in Pten-null mice.

However, following institutional investigations by Université Clermont Auvergne, it has come to our attention that much of the data reported in the paper were a result of manipulation or fabrication. Specifically, differences in protein expression in western blots presented in Fig. 1e, 3b, g, i, m, and 6b, and Supplementary Figures 2d, 6d, 6h, 7h, 8c, 8d, and 14 were generated by unequal loading of samples. In qPCR experiments presented in Figs. 1f, 3f, 4g, 5h, and 6a, d and Supplementary Figures 2c, 5d, 6g, 8d, 11a-c, and 12b, differences in expression level were manipulated through adjustment of cycle numbers, selection of samples, and data fabrication. Differences in immunostaining in Figs. 2g, k and 7e were obtained by selection of images or manipulation of exposure levels. Observed differences in relative luminescence units in Figs. 3m, 4e, and Supplementary Figures 6f, 7a, 7b, 10, and 11f were due to experiment selection.

In light of these findings, we have no confidence in the accuracy of the reported data and the conclusions of the paper. We therefore wish to retract the paper. We deeply regret these circumstances and apologize to the scientific community.

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Jean-Marc A. Lobaccaro or Silvère Baron.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Alioui, A., Dufour, J., Leoni, V. et al. Retraction Note: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer. Nat Commun 9, 2660 (2018). https://doi.org/10.1038/s41467-018-04653-3

Download citation

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.