Fig. 4 | Nature Communications

Fig. 4

From: A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis

Fig. 4

Overlap of inflammation-associated functional connectivity at both time points. a Positive connections between the default mode network (DMN) with the inferior parietal lobule (IPL), b dorsal attention network (DAN) and IPL, c the DAN and medial prefrontal cortex (mPFC) at baseline and 6 months that were associated with increased peripheral inflammation measured by erythrocyte sedimentation rate (ESR). Scatterplots showing the association between ESR and the strength of connectivity are displayed next to each brain region. Extracted average Fisher r values from 8 mm spheres derived from the significant peak cluster coordinates identified at session 1 (baseline) were used at session 2 (month 6) and these were correlated with concurrent ESR values using Pearson correlations at p < 0.05 uncorrected. Baseline regions are shown in orange, 6 months in blue. Displayed at p = 0.005 voxel threshold

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