Fig. 3 | Nature Communications

Fig. 3

From: A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis

Fig. 3

Overlap of inflammation-associated functional connectivity changes. a Brain regions (medial prefrontal cortex [mPFC], inferior parietal lobule [IPL]) showing positive connectivity to the different networks (medial visual network [MVN], default mode network [DMN], dorsal attention network [DAN], salience network [SLN]) at higher levels of peripheral inflammation measured by erythrocyte sedimentation rate (ESR). Area of reduced grey matter volume is shown in light blue. This was identified by testing the association of ESR with grey matter volume derived through voxel-based morphometry (VBM) in 8 mm spheres extracted around the significant peak cluster coordinates from the session 1 network to whole-brain connectivity analyses, in multiple linear regression analyses controlling for age and sex at p < 0.05 uncorrected. b Scatterplot showing the association between ESR and grey matter volume. Displayed at p = 0.005 voxel threshold corrected for age and sex

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