Fig. 4 | Nature Communications

Fig. 4

From: Postnatal DNA demethylation and its role in tissue maturation

Fig. 4

Effect of DNA methylation on chromatin accessibility. a ATAC-Seq of postnatal DMRs (2800 100 bp regions as determined by RRBS) as a function of distance from their center in WT (blue) and DKO (red) adult (15 weeks) hepatocytes. Also shown for comparison (lower panel) is an analysis of hepatocyte-specific prenatal DMRs that are already fully unmethylated (<5%) in 1 week hepatocytes (n = 1290). b ChIP-Seq of postnatal and prenatal DMRs for HNF6 as a function of distance from their center tile. All curves represent the average of two independent experiments

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