Fig. 6 | Nature Communications

Fig. 6

From: Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation

Fig. 6

Gene expression network mediated by transcriptional regulators. a Genes showing significant differential gene expression upon factor knockdowns, with 2-fold differential expression in at least one knockdown. b Fraction of expressed genes showing consistent up- or down-regulation upon 6 factor knockdowns compared to those obtained by randomizing each column of the datasets. c Dynamic regulation of gene expression of gene groups in a during transformation. The cumulative distribution function fold changes values (log2(transformed/non-transformed)) is plotted. d The gene transcription network mediated by the transcription factors. The edges represent direct factor binding sites in promoters/enhancers of targeted genes. For each pathway, 3 randomly picked genes are shown

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