Fig. 8 | Nature Communications

Fig. 8

From: Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

Fig. 8

Phosphatidylinositol 3-kinase (PI3K) inhibitory activity. a The inhibitory effects of compounds 114 against PI3K, with BEZ235 as the positive control. The inhibition ratio of a certain sample on PI3K was calculated according to the following formula: PI3K inhibition (%) = (ERsample – ER0%)/(ER100% − ER0%) × 100%, as described in method section. Data represent mean ± SD of two replicates. b The IC50 values of compounds 13, 7, 10, and BEZ235. The IC50 values were estimated using the “Sigmoidal dose-response (variable slope)” equation in the GraphPad Prism® Version 5.0 software. Data represent mean ± SD of two replicates

Back to article page