Fig. 3 | Nature Communications

Fig. 3

From: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis

Fig. 3

Molecular signatures of intrinsic subtypes of colorectal liver metastases. a Ensemble of gene set enrichment analyses (EGSEA) of significantly enriched “Hallmark” and “Cellular Estimate” gene signatures within each molecular subtype. Red color denotes enrichment, while blue color indicates depletion. Color intensity in EGSEA heatmaps is proportional to significance level (see Supplementary Data 4 and 5). Subtype 1 = red, Subtype 2 = green, Subtype 3 = blue. b Functional categorization of differentially expressed immune genes overexpressed in subtype 2. In heatmap red color denotes overexpression, while blue color indicates suppression. c OncoPrint plot of recurrent colorectal cancer mutations and copy number alterations by subtype. d Frequencies of subtype-specific genomic alterations. Asterisks denote statistical significance based on Fisher’s exact test comparing each subtype group to the two other subtypes. Subtype 1 = S1, Subtype 2 = S2, Subtype 3 = S3

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