Fig. 3 | Nature Communications

Fig. 3

From: Precisely timed inhibition facilitates action potential firing for spatial coding in the auditory brainstem

Fig. 3

Precisely timed, preceding inhibition underlies spike facilitation in vivo. a Schematic of the re-positioning of cTD-spike rate functions: functions were re-centered on each neurons’ min-cTD (illustrated by filled circles, only three schematic functions are shown here), resulting in an extended Δt-axis (–800 to 800 µs). This way, all cTD-response functions were normalized to the cTD of coincidence between excitation and inhibition (inset in top left panel). b Normalized Δt-spike rate functions at best ICI of each neuron (n = 17) after re-centering. c Median changes in spike rate relative to their respective response rate during Exc. only stimulation for the re-centered Δt-spike rate functions of all cells tested (n = 17). Next to the expected decrease of spike rates near Δt = 0, an increases in relative spike rate is apparent for Δt values of 600 µs (120.6%, P = 0.00007, paired Wilcoxon signed rank test) and 400 µs (16.3%, p 0.003, paired Wilcoxon signed rank test). Shaded area denotes interquartile ranges. d A similar dependency of response facilitation on Δt is apparent on the level of changes in firing rates to individual clicks (color-coded). Notably, facilitation increased with clicks later in the train (P = 0.01 and P = 0.002 at Δt = 600 µs and Δt = 400 µs, respectively, Friedman’s test). Data points are mean ± s.e.m