Fig. 2 | Nature Communications

Fig. 2

From: Precisely timed inhibition facilitates action potential firing for spatial coding in the auditory brainstem

Fig. 2

Inhibition enhances spiking throughout the click train. a Sample response rates (n = 17 neurons, median and interquartile range) to click-trains at different ICIs are shown during excitation only (orange), at min-cTD (yellow) and at max-cTD (brown). Both the ICI and the cTD of the click train significantly modulated spike rates (P-values derived from two-way ANOVA test). b Increasing the level on the contralateral ear (ipsilateral level un-changed) reduced the max rates, both if measured at the max cTD for the original ILD (dark brown, mean change ± s.e.m.: −26.34 ± 9.4%, P = 0.02, t-test, n = 9 neurons) and at the max cTD for the new ILD (light brown, −22.11 ± 6.9%, P = 0.01, t-test, n = 9 neurons). c Single-click spike rate analysis (n = 15): Normalized mean spike rates (normalization to mean response rates to the first click) decreased as a function of the individual clicks and ICI (two-way ANOVA, P(click) < 0.0001, F(5, 400) = 124.1; P(ICI) = 0.017, F(4, 80) = 3.2). Interactions between clicks and ICI were also significant (P < 0.0001, F(20, 400) = 2.76). d For ICIs >1 ms, the mean response rates at max-cTD were significantly higher than Exc. only response rates across all clicks (two-way ANOVA, P(click) = 0.032, F(5, 400) = 2.47; P(ICI) = 0.49, F(4, 80) = 0.87)