Fig. 3 | Nature Communications

Fig. 3

From: Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA

Fig. 3

Cardiac cfDNA dynamics during STEMI and after angioplasty. a Comparison of unmethylated FAM101A levels in healthy controls, and STEMI samples before and after PCI. Kruskal–Wallis test p-value < 0.0001. Dunn’s multiple comparisons test: Ctrls vs. pre-PCI, p-value = 0.0082; Ctrls vs. post-PCI (>0.03), p-value < 0.0001; per- vs post-PCI, p-value = 0. 0005. Horizontal red and gray lines represent the average value and standard deviation of cardiac cfDNA among the samples from each group. b ROC curve for the diagnosis of STEMI by cardiac cfDNA in healthy individuals versus STEMI patients prior to intervention. Area under the curve (AUC) 0.76, p-value = 0.0005. c Time course of cardiac cfDNA and troponin levels in representative individual patients. Vertical dashed lines indicate PCI time

Back to article page