Fig. 4 | Nature Communications

Fig. 4

From: Placental miR-340 mediates vulnerability to activity based anorexia in mice

Fig. 4

MiR-340 is associated with differential expression of nutrient transporters both in mouse and human female placenta. a Heat-map comparing placental nutrient transporters between female mice endogenously expressing high or low levels of miR-340. b The expression of Slc7a5, Slc7a11, Slc38a1, Slc16a3, Igf2, and Igf2bp1 is inversely correlated with miR-340 in mice. c Eosin-hematoxylin staining of the mouse placenta show a thicker junctional zone in the high miR-340 group (t(6) = 3.07, p = 0.022). d STRING pathway analysis linking the miR-340 targets Nr3c1, Cry2, and H3f3b with selected nutrient transporters (https://string-db.org). e Expression of miR-340 in the human placenta in central, medial, and lateral areas. Girls present higher levels in the central area compared to boys (two-way ANOVA F(1,104) = 14.78, p < 0.0001). Data are presented as mean and s.e.m. f The expression of SLC7A5, SLC7A11, SLC38A1, SLC16A3, IGF2, and IGF2BP1 are inversely correlated with miR-340 expression in the central area of human samples. Scale bar: 1 mm

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