Fig. 9 | Nature Communications

Fig. 9

From: Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Fig. 9

Immunolocalisation of AQP1, ATP13A3 and SOX17 in normal and PAH lung. The typical histological findings (haematoxylin and eosin staining) of concentric vascular lesions with associated plexiform lesions are shown (a). Higher magnification images of plexiform lesion (b), with frequent endothelialised channels (c; anti-CD31) surrounded by myofibroblasts (d; anti-SMα). Additional high magnification images demonstrating endothelial expression of ATP13A3 (e), AQP1 (f) and SOX17 (g) in PAH lung. Controls lung sections demonstrating predominantly endothelial expression of ATP13A3 (h), AQP1 (i) and SOX17 (j). (Scale bars = 50 µm)

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