Fig. 3 | Nature Communications

Fig. 3

From: Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Fig. 3

Manhattan plots of the rare variant analyses, having excluded cases carrying rare variants in previously established PAH genes. Filtered variants were grouped per gene. We tested for an excess of variants in PAH cases within genes using Fisher’s exact test. The negative decadic logarithm of unadjusted or adjusted P-values are plotted against the chromosomal location of each gene. a Burden test of rare PTVs. b Burden test of rare deleterious missense variants. c Burden test combining rare PTVs and likely deleterious missense variants. d SKAT-O test of rare PTVs and missense variants

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