Fig. 1 | Nature Communications

Fig. 1

From: Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Fig. 1

Flow diagrams illustrating a the composition of the NIHR BioResource—Rare Diseases (NIHR BR-RD) PAH study and b the analysis strategy to identify novel PAH disease genes. a The study comprised 1048 adult cases (aged 16 or over) attending specialist pulmonary hypertension centres from the UK (n = 731), and additional cases from France (n = 142), The Netherlands (n = 45), Germany (n = 82) and Italy (n = 48). b A series of case-control comparisons including and excluding cases with variants in previously reported disease genes were undertaken using complementary filtering strategies

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