Fig. 9 | Nature Communications

Fig. 9

From: Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

Fig. 9

Model for epigenomic and transcriptional dysregulation occurring with ATRX deficiency. ATRX inactivation alters chromatin structure and accessibility in the immediate vicinity of vacant ATRX binding sites (blue), in part due to shifts in the incorporation of H3.3. These changes induce the misexpression of locally situated genes, promoting the acquisition of disease-defining cellular phenotypes, such as motility and altered differentiation

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