Fig. 5 | Nature Communications

Fig. 5

From: Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

Fig. 5

Atrx deficiency alters chromatin accessibility genome-wide at vacant Atrx binding sites. a Volcano plot showing differentially accessible genomic sites (open or closed) arising with Atrx deficiency in mNPCs. b Sample trace showing the extent of overlap between Atrx ChIP-seq peaks (black) and ATAC-seq open (green) and closed (red) regions. c heat maps showing the spatial relationships between TSSs, enhancers (enh center), and differentially accessible regions arising in the context of Atrx deficiency. d Venn diagrams demonstrating significant overlaps between upregulated genes and genes approximating ATAC-open sites, and downregulated genes and genes approximating ATAC-closed sites (±10 kb; P values determined by hypergeometric test). e sample traces of astrocytic lineage markers or regulators showing their genomic associations with Atrx binding sites (black) and ATAC-seq open regions (green)

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