Fig. 6: | Nature Communications

Fig. 6

From: Activation of serotonin neurons promotes active persistence in a probabilistic foraging task

Fig. 6

The effect of DRN 5-HT photostimulation on the microstructure of behavior. a Example trial represented in real time and starting from the last reward in that trial. Top: Each rectangle represents a single nose-poke (green marks the last reward and gray the subsequent omissions). Middle: estimated hazard for each nose-poke. Bottom: omission duty cycle (ODC). b Correlation between ODC and estimated hazard. The red line is a linear regression curve, with its correlation coefficient shown as well (p < 0.001). c Rewards reverse an overall (across trial) monotonic decrease in ODC (red) and an overall increase in hazard (black). The plot shows the average ODC and hazard as a function of poke number, aligned on the last reward and averaged across the population of mice (n = 16). Note that despite a decreasing (increasing) trend, the ODC (hazard) immediately after the last reward is higher (lower) than the one just before it. d Difference between average ODC and hazard immediately before the last reward compared to immediately after it across the population of mice (n = 16). *p < 0.05, Wilcoxon signed-rank test. e Left: The ODC for an example SERT-Cre mouse for phostostimulated and control nose-pokes aligned on last reward. The dashed lines are linear regression curves (p < 0.001 for the phostostimulation coefficient). Right: Regression photostimulation coefficients for SERT-Cre (n = 10) and wild-type (n = 6) mice. Averages across mice are shown in filled circles. *p < 0.05, Wilcoxon rank-sum test. f Left: The ODC for the same SERT-Cre mouse shown in d for phostostimulated and control nose-pokes as a function of estimated hazard. The dashed lines are linear regression curves, (p > 0.05 for the phostostimulation coefficient). Right: Regression photostimulation coefficients for SERT-Cre (n = 10) and wild type (n = 6) mice. Averages across mice are shown in filled circles. p > 0.05, Wilcoxon rank-sum test