Figure 4: Nature Communications

Fig. 4

From: Activation of serotonin neurons promotes active persistence in a probabilistic foraging task

Fig. 4

Lack of effect of DRN 5-HT photostimulation on travel duration. a Schematic diagram of task events during a single trial showing the period of photostimulation. In the first protocol (photostimulation while poking), photostimulation was triggered by the first poke in 50% of correct trials, and in the second protocol (photostimulation while traveling), photostimulation was triggered by ROI exit in 50% of the correct trials and lasted for 2 s. We also defined two relevant time periods: (T1) time-to-leave—the interval between the last poke and ROI exit, and (T2) travel—the interval between ROI exit and subsequent ROI entry. b Left: Cumulative distributions of T1 durations for photostimulated (blue) and control (black) trials, averaged across the population of SERT-Cre mice (n = 10) in the photostimulation-during-poking protocol. Right: Bar plot showing the corresponding averages. *p < 0.05, Wilcoxon signed-rank test. c Left: Cumulative distributions of T2 durations for photostimulated (blue) and control (black) trials, averaged across the population of SERT-Cre mice (n = 10) in the photostimulation-during-poking protocol. Right: Bar plot showing the corresponding averages. p > 0.05, Wilcoxon signed-rank test. d Left: Cumulative distributions of T2 durations for photostimulated (blue) and control (black) trials, averaged across the population of SERT-Cre mice (n = 6) in the photostimulation-during-traveling protocol. Right: Bar plot showing the corresponding averages. p > 0.05, Wilcoxon signed-rank test