Figure 3: Nature Communications

Fig. 3

From: Activation of serotonin neurons promotes active persistence in a probabilistic foraging task

Fig. 3

The effect of DRN 5-HT photostimulation on switching behavior. a Scheme of the locations of ChR2-YFP expression and optic fiber placement (adapted with permission from ref. 63). b Schematic diagram of task events during a single trail, also showing the period of photostimulation. Photostimulation was triggered by the first poke in 50% of correct trials and ended either when the mouse left the ROI or if 10 s had elapsed since the last poke. c Distributions of the number of pokes per trial for photostimulated trials (blue) and control trials (black) averaged across the population of SERT-Cre mice (n = 10). d Distributions of the number of pokes per trial for photostimulated (green) and control (black) trials, across the population of wild-type mice (n = 6). e Difference between average number of pokes in photostimulated and control trials for SERT-Cre (n = 10) and wild-type (n = 6) mice. Averages across mice are shown in filled circles. *p < 0.05, Wilcoxon rank-sum test. f Plot showing the average number of pokes in photostimulated and control trials for SERT-Cre mice (n = 10) as a function of consecutive numbers of photostimulated (blue) or control (black) trials. There was no effect of sequence length on behavior, p > 0.05, linear regression analysis