Fig. 3 | Nature Communications

Fig. 3

From: A systematic approach to the development of a safe live attenuated Zika vaccine

Fig. 3

Immune-restriction of DN-2 replication confers small-plaque phenotype. Plaque sizes of DN-1, DN-2, and H/PF/2013 after siRNA knockdown of IRF3 in BHK-21 cells. Western blot analysis of cells was performed 48 h after siRNA transfection to determine knockdown efficiency as shown in the cropped blots (representative data of three experiments). Error bars represent s.d. ****p < 0.0001 in unpaired t test

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